Amy Mathers, MD, Professor of Medicine and Pathology at the University of Virginia is an infectious diseases physician scientist, clinical microbiologist, and hospital epidemiologist whose research focuses on plasmid transmission and the development of genomic tools to understand and reduce antimicrobial resistance gene transmission in healthcare settings. Her work emphasizes the role of environmental reservoirs in the persistence and spread of antimicrobial resistance within hospitals. She currently leads translational and genomic research integrating clinical microbiology, infection prevention, and pathogen genomics to investigate antimicrobial resistance transmission dynamics and develop practical interventions for healthcare systems.