Dr. Christian Lesterlin has been a team leader in the Molecular Microbiology and Structural Biochemistry unit at the University of Lyon since 2015. He is a trained geneticist whose research addresses fundamental and applied aspects of bacterial conjugation, with particular relevance to the spread of antimicrobial resistance (AMR). His work has established live-cell, real-time approaches to visualize and quantify DNA transfer in bacteria, leading to the identification of key spatial and temporal features of conjugative DNA transport, chromosome organization, and plasmid behavior during cell-to-cell transfer (Lab Website). By developing original genetic systems and fluorescent reporters, his group has provided mechanistic insight into how conjugation operates at single-cell and population scales. In parallel, these findings have supported the development of targeted antibacterial plasmids (TAPs) as a strategy to interfere with AMR dissemination. This work is documented in peer-reviewed publications (Lesterlin C. PubMeb link).